Saltram is situated on Angaston Road, on the Western Ridge from the town of Angaston in the Barossa Valley. Saltram draws fruit from its 45-hectare Saltram Vineyard that surrounds the Saltram Winery and Cellar Door and from other vineyards throughout the region. These vineyards are spread over the cooler hills of the Eden Valley to the warmer areas across the valley floor.
The Saltram Vineyard has many varieties planted, with the majority planted Shiraz and Cabernet Sauvignon, alongside some smaller plantings of non-mainstream varieties such as Tempranillo and Sangiovese.
Most of Saltram vines are irrigated via drip irrigation and supported on a variety of trellising systems with more recent planting on single wire trellising and t-trellising systems. Drip irrigation was developed in the 1950's to allow viticulturists to grow grapevines in climates with low rainfall.